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Mitochondria |
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Molecular Changes |
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Hematopietic System Aging |
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Mitochondrial Dysfunction |
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DNA |
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Mitochondria are organelles responsible for the generation of most of the chemical energy of cells. They have their own DNA and RNA, as well as a complete system of transcription and translation, allowing them to synthesize some of their own proteins. |
| EXPERIMENT INFORMATION |
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Brazil |
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multiple racial |
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39/21 |
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64.5/64.0/66.0 |
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17/43 |
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Functional |
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No correlation was found between age and mtdna-cn, but a direct correlation was observed for cases with mtdna-cn >1000 (r = 0.41). the mtdna-cn >1000 group had greater tissue autofluorescence and higher body mass index compared to the mtdna-cn <1000 group (bmi; 25.7 vs 22.0 kg/m2, respectively). mtdna-cn correlated with tissue autofluorescence in the overall sample (r = 0.55) and in the t2d group (r = 0.64). pink and prkn expressions were inversely correlated with age. mitochondriogenesis genes and txnip expressions were higher in the t2d group, and correlations among the mitochondriogenesis genes were also stronger in this group, relative to the subgroup with mtdna-cn >1000. |
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Suely Kazue Nagahashi Marie, Exp Gerontol., 2022 |
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PMID:35995312 (Click to Pubmed) ； IF: ； Citation: |
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