| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Serum Alanine Aminotransferase (ALT) |
Category |
Molecular Changes |
Affected targets |
Liver Aging |
Hallmarks |
Genomic Instability |
Molecular |
Protein |
Description |
Serum alanine aminotransferase (ALT) level is frequently used as a surrogate marker for hepatocyte injury. Normal ranges vary according to the commercial kit used, but have historically been set at around 40 IU/L. |
| EXPERIMENT INFORMATION | |
Region |
USA |
Race |
white |
Samples |
2364 |
Age |
30-62/63-71/72-77/78-93 |
Gender |
1044/1320 |
Application |
Predictive |
Conclusion |
Alt levels decrease with age in both men and women independent of metabolic syndrome components, adiposity signaling biomarkers, and other commonly used liver function tests. further studies are needed to understand the mechanisms responsible for a decline in alt with age, and to establish the optimal cut-point of normal alt in the elderly. |
Reference |
Rohit Loomba, PLoS One, 2010 |
Details |
PMID:21170382 (Click to Pubmed) ； IF: ； Citation: |
Confidence |