| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Alanine Aminotransferase |
Category |
Molecular Changes |
Affected targets |
Liver Aging |
Hallmarks |
Loss of Proteostasis |
Molecular |
Protein |
Description |
One of the key clinical markers of fatty liver is raised blood activity of alanine transaminase (ALT), which is an enzyme released from damaged hepatocytes |
| EXPERIMENT INFORMATION | |
Region |
Australia |
Race |
white |
Samples |
1673 |
Age |
70-97 |
Gender |
1673/0 |
Application |
Functional |
Conclusion |
In conclusion, low circulating alt activity was found to be associated with aging and frailty in old men and to be a predictor of their subsequent survival.? the effect of alt on mortality was mediated via its association with frailty and aging.? alt may be a useful biomarker for aging and frailty and should be considered for future studies, especially because the decrease in alt with age and frailty was greater than that seen with albumin. |
Reference |
Robert G. Cumming, J Gerontol A Biol Sci Med Sci, 2010 |
Details |
PMID:20498223 (Click to Pubmed) ； IF: ； Citation: |
Confidence |