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Apolipoprotein E (APOE) ε4 |
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Molecular Changes |
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Brain Aging |
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Loss of Proteostasis |
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DNA |
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Apolipoprotein E (APOE) ε4, the strongest genetic risk factor for late onset Alzheimer's disease (LOAD), has been associated with cognitive decline independent from AD pathology. |
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UK |
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multiple racial |
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500000 |
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40-70 |
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/ |
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Predictive |
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While prs-load including all variants (except apoe) predicted cognitive level, apoe ε4 and prs-load based on 17 non-apoe gene variants with strong association to ad (p < 5e-8) predicted age-related decline in verbal numeric reasoning. the effect on decline were partly driven by 4 variants involved in the immune system. those variants also predicted serum levels of the inflammatory marker c-reactive protein (crp), but crp did not mediate the effect on decline. those findings suggest genetic variations in immune functions play a role in aspects of cognitive aging that may be independent of load pathology as well as systemic inflammation measured by crp. |
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Adil?Supiyev, Neurobiology of Aging, 2023 |
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PMID:36965205 (Click to Pubmed) ； IF: ； Citation: |
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