| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
CD8+ T cells |
Category |
Cellular Alterations |
Affected targets |
Immune System Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
The CD8?T-cell population loses proper responsiveness at old age |
| EXPERIMENT INFORMATION | |
Region |
Netherlands(Northern Netherlands) |
Race |
white |
Samples |
50(symptomatic)/15(symptomatic) |
Age |
21-82/63-83 |
Gender |
/ |
Application |
Predictive |
Conclusion |
Together, our study indicates that co-expression of tigit and helios provides a novel useful marker to better define immunosenescent cd8?t cells. moreover, we show that these cells already accumulate in the intermediate-differentiation stage in older individuals. these findings challenge the current dogma of late-differentiation stage as a sole proxy for t-cell immunosenescence. these insights may refine future interpretation of studies on impaired cd8?t-cell mediated immunity to viral infections at old age.++. |
Reference |
Teun Guichelaar, Front Immunol, 2022 |
Details |
PMID:35651622 (Click to Pubmed) ； IF: ； Citation: |
Confidence |