| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Relative Telomere Length (RTL) |
Category |
Molecular Changes |
Affected targets |
Skin Aging |
Hallmarks |
Telomere Attrition |
Molecular |
Other |
Description |
Relative telomere length (RTL) is a biomarker for physiological aging |
| EXPERIMENT INFORMATION | |
Region |
worldwide |
Race |
multiple racial |
Samples |
2262(627(AMD)/1635(without AMD)) |
Age |
70-95 |
Gender |
1077/1185 |
Application |
Functional |
Conclusion |
In this study, we found an association between shorter rtl and amd in an elderly population independent from potential risk factors. this association was present only in women and not in men, driven by biological age and to some extent independent from chronological age. our results are in line with a sex-differential pathway from oxidative stress to amd. further studies on the progression of the disease including follow-up data are required for a better understanding of the pathomechanisms of amd. |
Reference |
Florian Kronenberg, Invest Ophthalmol Vis Sci, 2022 |
Details |
PMID:35612837 (Click to Pubmed) ； IF: ； Citation: |
Confidence |