| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Advanced Glycation End-products (AGEs) |
Category |
Molecular Changes |
Affected targets |
Skeletal Muscle Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
Protein |
Description |
Advanced glycation end-products (AGEs) are end products of protein glycation that bind to the receptor for AGEs (RAGE) and activate nicotinamide adenine dinucleotide phosphate oxidase (NOX), resulting in increased oxidative stress and rotator cuff fragility. |
| EXPERIMENT INFORMATION | |
Region |
Asia |
Race |
yellow |
Samples |
12 |
Age |
62.3 |
Gender |
/ |
Application |
Functional |
Conclusion |
Stump classification type 3 exhibited the highest accumulation of ages and the highest oxidative stress and apoptosis, suggesting a high degree of degeneration and inflammation. imaging based on stump classification reflects the degeneration and fragility of the torn rotator cuff site. |
Reference |
Ryosuke Kuroda, Am J Sports Med, 2022 |
Details |
PMID:35486520 (Click to Pubmed) ； IF: ； Citation: |
Confidence |