| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Magnetic Resonance Imaging (MRI) |
Category |
Imaging Traits |
Affected targets |
Brain Aging |
Hallmarks |
Other |
Molecular |
Other |
Description |
Statistical effects of cortical metrics derived from standard T1‐ and T2‐weighted magnetic resonance imaging (MRI) images, such as gray–white matter contrast (GWC), boundary sharpness coefficient (BSC), T1‐weighted/T2‐weighted ratio (T1w/T2w), and cortical thickness (CT), are often interpreted as representing or being influenced by intracortical myelin content. |
| EXPERIMENT INFORMATION | |
Region |
Canada |
Race |
multiple racial |
Samples |
174 |
Age |
69.9±5.6/45.8±16.1 |
Gender |
79/95 |
Application |
/ |
Conclusion |
We conclude that the microstructural properties at the source of spatial distributions of mri cortical markers (e.g., gm myelin) can be different from microstructural changes that affect these markers in aging. this warrants care in interpreting the age‐ or disease‐related effects of these mri markers when aiming to show changes in a specific property of the cortical microstructure. |
Reference |
Olivier Parent, Hum Brain Mapp, 2023 |
Details |
PMID:36896711 (Click to Pubmed) ； IF: ； Citation: |
Confidence |