| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Magnetic Resonance Imaging (MRI) |
Category |
Imaging Traits |
Affected targets |
Brain Aging |
Hallmarks |
Deregulated Nutrient Sensing |
Molecular |
Other |
Description |
A common observation in fMRI studies using the BOLD signal is that older adults, compared with young adults, show overactivations, particularly during less demanding tasks. |
| EXPERIMENT INFORMATION | |
Region |
Sweden |
Race |
multiple racial |
Samples |
57 |
Age |
71.09/25.2 |
Gender |
45545 |
Application |
Functional |
Conclusion |
Findings of increased fmri activations in older compared with younger adults have been suggested to reflect increased use of neuronal resources to cope with reduced brain function. comparing fmri and simultaneously acquired functional positron emission tomography as an alternative index of synaptic activity, we show that age-related overactivations do not appear to be neuronal in origin. this result is important because mechanisms underlying compensatory processes in aging are potential targets for interventions aiming to prevent age-related cognitive decline. |
Reference |
Lars Stiernman, Journal of Neuroscience, 2023 |
Details |
PMID:36868855 (Click to Pubmed) ； IF: ； Citation: |
Confidence |