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Myeloid-derived suppressor cells (MDSCs) |
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Cellular Alterations |
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Immune System Aging |
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Stem Cell Exhaustion |
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Other |
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid precursor cells that function as negative regulators of immune responses by inhibiting T cell proliferation, IFN-gamma production, and CTL induction and have been reported to play important roles in the development of microbial inflammation and infection |
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white |
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57 |
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18-92 |
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26/31 |
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Functional |
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Collectively, our data demonstrate that a detrimental cross-talk occurs in elders' bm, resulting in the induction of suppression in i-mdscs and adipogenesis in bm-mscs, most likely induced or maintained by both cell–cell contacts and il-6. these results open up new possibilities for defining markers and targets for preventive or therapeutic strategies in aging to eventually regulate immunity, inflammation, and bone resorption in elders. |
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Maria Elisa Perico, Cells, 2022 |
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PMID:35011569 (Click to Pubmed) ； IF: ； Citation: |
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