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HIV-1 Reservoir |
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Molecular Changes |
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Immune System Aging |
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Telomere Attrition |
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DNA |
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Persistence of HIV-1, causing chronic immune activation, is a key determinant of premature senescence. HIV-1 positive children display higher percentages of activated and senescent CD8 cells, which inversely correlate with telomere length, thus supporting the link between biological ageing and immunosenescence. |
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Europe |
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multiple racial |
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37 |
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13.8(9-16.7) |
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45651 |
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Functional |
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This study investigates for the first time the association between hiv-1 reservoir and telomere shortening, thymic output and immunosenescence in a unique cohort of long-term virally suppressed adolescents who initiated art early in life. we show that early art initiation restricts the size of viral reservoir and prevents premature immunosenescence and telomere shortening. timing of art initiation in infancy is crucial and has long-term consequences on the immune and biological ageing profile. |
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Paolo Rossi, Anita De Rossi, J Int AIDS Soc., 2021 |
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PMID:34797948 (Click to Pubmed) ； IF: ； Citation: |
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