| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
MicroRNA-200 family |
Category |
Molecular Changes |
Affected targets |
Instestinal Aging |
Hallmarks |
Cellular Senescence |
Molecular |
DNA |
Description |
Genetic deletion of all miR-200s in the human GC cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated beta-galactosidase (SA-beta-gal) activity, and aberrant metabolism, collectively resembling the senescent phenotype. |
| EXPERIMENT INFORMATION | |
Region |
worldwide |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
Our work has identified a new role of mir-200 family members which function as an integrated unit serving to link senescence with emt, two major conserved biological processes. |
Reference |
Jikun Li, Oncogene, 2022 |
Details |
PMID:34667277 (Click to Pubmed) ； IF: ； Citation: |
Confidence |