| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Atrial Fibrillation |
Category |
Molecular Changes |
Affected targets |
Cardiac Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
Other |
Description |
The most prominent risk factor for atrial fibrillation (AF) is chronological age; however, underlying mechanisms are unexplained. Algorithms using epigenetic modifications to the human genome effectively predict chronological age. |
| EXPERIMENT INFORMATION | |
Region |
Canada,USA |
Race |
/ |
Samples |
5600 |
Age |
/ |
Gender |
2234/3366 |
Application |
Functional |
Conclusion |
Our study identified adjusted associations between eaa measures and incident af, suggesting that biological aging plays an important role independent of chronological age, though a potential underlying causal relationship remains unclear. these aging processes may be modifiable and not constrained by the immutable factor of time. |
Reference |
Gregory M Marcus, Circulation, 2021 |
Details |
PMID:34587750 (Click to Pubmed) ； IF: ； Citation: |
Confidence |