| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Allotransplantation |
Category |
Independent Events |
Affected targets |
Adipose Tissue Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
Given that inflammation related to chronic viral infection is known to induce NK-like marker expression and a senescence phenotype among CD8 T-cells, we hypothesized that innate E(+) CD8 T-cells will be preferentially associated with exacerbated cellular senescence in response to chronic alloantigen exposure or CMV infection |
| EXPERIMENT INFORMATION | |
Region |
France |
Race |
multiple racial |
Samples |
46/23 |
Age |
66/46 |
Gender |
43/26 |
Application |
Functional |
Conclusion |
We propose that kidney transplantation,viathe setting of inflammatory stimuli of alloantigen exposure and cmv infection, may exogenously age the cd8 t-cell compartment, especially innate e(+) cd8 t-cells. |
Reference |
Alice Barbarin, Frontiers in Immunology, 2021 |
Details |
PMID:34367138 (Click to Pubmed) ； IF: ； Citation: |
Confidence |