| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Plasminogen Activator Inhibitor 1 (PAI-1) |
Category |
Cellular Alterations |
Affected targets |
Lung Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Protein |
Description |
Plasminogen activator inhibitor (PAI-1) is considered as a critical marker and mediator of cellular senescence. |
| EXPERIMENT INFORMATION | |
Region |
China |
Race |
/ |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
In conclusion, our work strongly demonstrated that the gasotransmitter co could protect lung fibroblasts against bleomycin-induced premature senescence by inducing sg formation, promoting the sequestration of pai-1 into sgs, as well as controlling the telomere shortening. |
Reference |
Liping Liu, Oxid Med Cell Longev., 2021 |
Details |
PMID:34306316 (Click to Pubmed) ； IF: ； Citation: |
Confidence |