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Extracellular Matrix (ECM) |
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Cellular Alterations |
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Lung Aging |
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Cellular Senescence |
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Other |
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Changes in the ECM of the lung during ageing, such as loss of elastin and increased collagen contributes to aberrant composition that negatively influences proliferation, migration and differentiation of cells. Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease of unknown aetiology that is characterised by exaggerated deposition of extracellular matrix (ECM) leading to an irreversible decline in lung function and ultimately death. |
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worldwide |
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white |
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Predictive |
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In conclusion, we have shown that fibroblast exposed to ctrl- or ipf-derived ecm under nonstimulated conditions does not induce cellular senescence. instead, we observed upregulation of proinflammatory cytokines and profibrotic cytokines in response to senescent or profibrotic ecm. these data suggest that, to induce a strong response to their environment, not only is composition important in ipf but a secondary stimulant that induces dna damage such as ros, or pathological stiffness might be required to create a positive feedback look that perpetuates fibrosis in ipf. |
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Kaj E C Blokland, Cells., 2021 |
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PMID:34209854 (Click to Pubmed) ； IF: ； Citation: |
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