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DNAmFitAge |
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Molecular Changes |
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Whole Body |
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Epigenetic Alterations |
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DNA |
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We then use these DNAm fitness biomarkers to develop the novel DNAm fitness-related biological age indicator, DNAmFitAge, which quantifies the relationship between physical fitness and biological aging processes. This novel measure incorporates mortality risk with strength, mobility, and cardiovascular fitness using blood DNAm biomarkers. Our newly constructed DNAm biomarkers and DNAmFitAge provide researchers and physicians a new method to incorporate physical fitness into epigenetic clocks and emphasizes the effect lifestyle has on the aging methylome. |
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worldwide |
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multiple racial |
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Predictive |
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Overall, dnamgaitspeed, dnamgripmax, dnamfev1, dnamvo2max, and dnamfitage provide epigenetic components to evaluating a person's physical fitness. physically fit people have a younger dnamfitage and younger fitageacceleration, and younger values are associated with more physical activity and better age-related outcomes. our research suggests exercise and stronger fitness parameters are protective to dnamfitage in both sexes. we expect dnamfitage will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions. |
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Steve Horvath, Aging (Albany NY), 2023 |
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PMID:36812475 (Click to Pubmed) ； IF: ； Citation: |
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