| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Lipid Oxidation Products |
Category |
Molecular Changes |
Affected targets |
Reproductive System Aging |
Hallmarks |
Altered Intercellular Communication |
Molecular |
Other |
Description |
By contrast, lipid components of the SASP are understudied. We show that senescent cells activate the biosynthesis of several oxylipins that promote segments of the SASP and reinforce the proliferative arrest. Notably, senescent cells synthesize and accumulate an unstudied intracellular prostaglandin, 1a,1b-dihomo-15-deoxy-delta-12,14-prostaglandin J2. Released 15-deoxy-delta-12,14-prostaglandin J2 is a biomarker of senolysis in culture and in vivo. |
| EXPERIMENT INFORMATION | |
Region |
Europe |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
These data identify an important aspect of cellular senescence and a method to detect senolysis. |
Reference |
Christopher D Wiley, Cell Metab, 2021 |
Details |
PMID:33811820 (Click to Pubmed) ； IF: ； Citation: |
Confidence |