| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Transforming Growth Factor Beta (TGF-β) |
Category |
Cellular Alterations |
Affected targets |
Pancreatic Aging |
Hallmarks |
Stem Cell Exhaustion |
Molecular |
Other |
Description |
Epithelial-mesenchymal transition (EMT) is a plausible mechanism of SCP tumorigenesis [4]. In addition, transforming growth factor-beta (TGF-beta) is known to induce EMT [5, 6]. |
| EXPERIMENT INFORMATION | |
Region |
Japan |
Race |
multiple racial |
Samples |
3 |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival. |
Reference |
Takanori Goi, World journal of surgical oncology, 2021 |
Details |
PMID:33726729 (Click to Pubmed) ； IF: ； Citation: |
Confidence |