| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Dual-parameter recognition fluorescent probe |
Category |
Others |
Affected targets |
Whole Body |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
This probe remains silent in non-senescent cells, yet produces bright fluorescence after sequential responses to two senescence-associated markers, namely, SA-beta-gal and MAO-A. In-depth studies reveal that this probe allows for high-contrast imaging of senescence, independent of the cell source or stress type. More impressively, such dual-parameter recognition design further allows it to distinguish senescence-associated SA-beta-gal/MAO-A from cancer-related β-gal/MAO-A, compared to commercial or previous single-marker detection probes. |
| EXPERIMENT INFORMATION | |
Region |
China |
Race |
yellow |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Predictive |
Conclusion |
This study offers a valuable molecular tool for imaging cellular senescence, which is expected to significantly expand the basic studies on senescence and facilitate advances of senescence-related disease theranostics. |
Reference |
Weihong Tan, Anal Chem, 2023 |
Details |
PMID:36795559 (Click to Pubmed) ； IF: ； Citation: |
Confidence |