| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
MTS1 (Multiple Tumor Suppressor 1) |
Category |
Cellular Alterations |
Affected targets |
Lung Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
We observed that the senescent marker p16 is predominantly localized to bronchiolized epithelial structures in scarred regions of IPF and systemic sclerosis-associated interstitial lung disease (SSc-ILD) lung tissue, overlapping with the basal epithelial markers Keratin 5 and Keratin 17. |
| EXPERIMENT INFORMATION | |
Region |
USA |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
We identified a population of basal epithelial cells defined by, and enriched for, markers of cellular senescence and identified candidate markers specific to senescent basal epithelial cells in ild that can enable future functional studies. notably, gene expression of these cells significantly overlaps with terminally differentiating cells in stratified epithelia, where it is driven by p53 activation as part of the senescence program. |
Reference |
Joseph R Arron, JCI insight, 2021 |
Details |
PMID:33705361 (Click to Pubmed) ； IF: ； Citation: |
Confidence |