| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Nicotinamide adenine dinucleotide (NAD+) |
Category |
Molecular Changes |
Affected targets |
Whole Body |
Hallmarks |
Genomic Instability |
Molecular |
Other |
Description |
Aging and age-related diseases has been reported to be closely associated with age-related decline in blood and tissue nicotinamide adenine dinucleotide (NAD+) content . Moreover, preclinical studies revealed that the administration of NAD?+?-related metabolites, such as nicotinamide (NAM), nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR), reverses the aging-related decline in physiological function and prevents the onset of age-related diseases partly via the activation of NAD?+?dependent deacetylase sirtuin. |
| EXPERIMENT INFORMATION | |
Region |
Japan |
Race |
yellow |
Samples |
42 |
Age |
65-88 |
Gender |
42/0 |
Application |
Anti-Aging |
Conclusion |
We identified negative correlations between blood concentrations of na and hearing ability at 1000 and 2000?hz. nad+ metabolic pathway might be associated with arhl onset or progression. further studies are warranted. |
Reference |
Toshimasa Yamauchi, BMC Geriatr, 2023 |
Details |
PMID:36792992 (Click to Pubmed) ； IF: ； Citation: |
Confidence |