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H2A.Z |
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Molecular Changes |
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Pancreatic Aging |
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Stem Cell Exhaustion |
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Protein |
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the histone variant H2A.Z is highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlates with poor prognosis. Moreover, all three H2A.Z isoforms (H2A.Z.1, H2A.Z.2.1, and H2A.Z.2.2) are highly expressed in PDAC cell lines and PDAC patients. Knockdown of these H2A.Z isoforms in PDAC cell lines induces a senescent phenotype, cell cycle arrest in phase G2/M, increased expression of cyclin-dependent kinase inhibitor CDKN2A/p16, SA-beta-galactosidase activity and interleukin 8 production. |
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Mexico |
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multiple racial |
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Functional |
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Therefore, our data suggest that overexpression of h2a.z isoforms enables cells to overcome the oncoprotective barrier associated with senescence, favoring pdac tumor grow and chemoresistance. these results make h2a.z a potential candidate as a diagnostic biomarker and therapeutic target for pdac. |
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R Hernández-Rivas, Oncogene, 2021 |
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PMID:33627784 (Click to Pubmed) ； IF: ； Citation: |
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