| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Short Telomere |
Category |
Molecular Changes |
Affected targets |
Lung Aging |
Hallmarks |
Telomere Attrition |
Molecular |
Other |
Description |
Chronic obstructive pulmonary disease (COPD) is a disorder of accelerated lung aging. Multiple pieces of evidence support that the aging biomarker short telomeres, which can be caused by mutations in telomerase reverse transcriptase (TERT), contribute to COPD pathogenesis. |
| EXPERIMENT INFORMATION | |
Region |
/ |
Race |
white |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
Collectively, our data suggest that functional tert snps with mild catalytic defects are nonetheless implicated in the clinical presentation of copd. |
Reference |
Judy M Y Wong, Scientific reports, 2021 |
Details |
PMID:33619289 (Click to Pubmed) ； IF: ； Citation: |
Confidence |