| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
DNA Damage Response (DDR) Signals |
Category |
Molecular Changes |
Affected targets |
Hematopietic System Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
DNA |
Description |
DDR-associated parameters, including endogenous DNA damage (single-strand breaks and double-strand breaks (DSBs) measured by the alkaline comet assay (Olive Tail Moment (OTM); DSBs-only by γH2AX immunofluorescence staining), DSBs repair capacity, oxidative stress, and apurinic/apyrimidinic sites were evaluated in PBMCs |
| EXPERIMENT INFORMATION | |
Region |
/ |
Race |
/ |
Samples |
243 |
Age |
38 |
Gender |
45612 |
Application |
Predictive |
Conclusion |
Prospective studies confirming the value of dna damage accumulation as a biomarker of aging, as well as the presence of a relevant agethreshold. |
Reference |
Petros Psfikakis, International Journal of Molecular Sciences, 2023 |
Details |
PMID:37108309 (Click to Pubmed) ； IF: ； Citation: |
Confidence |