| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
miR-409-3p |
Category |
Molecular Changes |
Affected targets |
Whole Body |
Hallmarks |
Stem Cell Exhaustion |
Molecular |
RNA |
Description |
Numerous studies indicated that microRNA (miR or miRNA) is involved in post-transcriptional regulation of gene expression concerning diverse biological functions, including ageing and angiogenesis. A previous report showed that angiogenesis and tissue repair were regulated by miRNA-135a-3p via targeting p38 signalling in endothelial cells, revealing a link among miRNA, angiogenesis and endothelial cells |
| EXPERIMENT INFORMATION | |
Region |
Asia |
Race |
yellow |
Samples |
57 |
Age |
25.8±0.9/69.7±0.5 |
Gender |
32/25 |
Application |
Functional |
Conclusion |
In summary, hsa-mir-409-3p was upregulated in senescent epcs and acted as a negative modulator of angiogenesis via targeting protein phosphatase 2 catalytic subunit alpha (ppp2ca) gene and regulating pp2a/p38 signalling. data from human pbmcs suggested hsa-mir-409-3p a potential biomarker for human ageing. |
Reference |
Cheng-Huang Su, J Cell Mol Med, 2023 |
Details |
PMID:36756741 (Click to Pubmed) ； IF: ； Citation: |
Confidence |