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Lysophospholipids and Branched-Chain Amino Acids |
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Cellular Alterations |
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Whole Body |
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Mitochondrial Dysfunction |
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Other |
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LPC and LPE are important precursors for the biosynthesis of phospholipids (PLs), including phosphatidylcholine (PC) and phosphatidylethanolamine (PE), which are essential for maintaining the structure and function of biological membranes (including mitochondrial membranes). We observed that serum levels of six LPC and ten LPE were down-regulated in older adults compared to young. In the Baltimore Longitudinal Study of Aging, lower plasma LPC was correlated with impairment of mitochondrial oxidative capacity after adjusting for age, sex, and height |
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Asia |
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yellow |
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32(old)/32(youth) |
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60(over)/36-59 |
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Functional |
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We preliminarily revealed the metabolite changes associated with aging in chinese adults. decreases in mitochondrial membrane-related lysophospholipids and dysfunction of branched-chain amino acid metabolism were determined to be the characteristics and promising research targets for aging. |
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Lina Ma, Eur J Med Res, 2023 |
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PMID:36732870 (Click to Pubmed) ； IF: ； Citation: |
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