| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Telomere Length and Beta-Galactosidase Activity |
Category |
Molecular Changes |
Affected targets |
Lung Aging |
Hallmarks |
Telomere Attrition |
Molecular |
Other |
Description |
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with age.In a prospective study, we measured TL by Flow-FISH in 70 hospitalized COVID-19 patients and compared TL distribution with our reference cohort of 491 healthy volunteers. |
| EXPERIMENT INFORMATION | |
Region |
Europe |
Race |
multiple racial |
Samples |
70 |
Age |
63 |
Gender |
22/48 |
Application |
Predictive |
Conclusion |
Lung tissue from patients with very short telomeres exhibit signs of senescence in structural and immune cells. our results suggest that tl influences the severity of the disease. |
Reference |
Antoine Froidure, Aging (Albany NY), 2020 |
Details |
PMID:33104521 (Click to Pubmed) ； IF: ； Citation: |
Confidence |