| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Deletion of complement factor H-related genes 1 and 3 (delCFHR3-1) |
Category |
Molecular Changes |
Affected targets |
Kidney Aging |
Hallmarks |
Cellular Senescence |
Molecular |
DNA |
Description |
DelCFHR3-1 mediates cellular senescence through complement |
| EXPERIMENT INFORMATION | |
Region |
USA |
Race |
multiple racial |
Samples |
67 |
Age |
71 |
Gender |
/ |
Application |
Functional |
Conclusion |
These data support both the role of fhr1 in mediating complement activation and tubular senescence, and suggest the possibility of genotyping delcfhr3-1 to predict graft survival in igan-transplanted patients. |
Reference |
Francesco Pesce, Am J Transplant, 2021 |
Details |
PMID:33091234 (Click to Pubmed) ； IF: ； Citation: |
Confidence |