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Red Cell Distribution Width (RDW) |
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Cellular Alterations |
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Skeletal Aging |
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Genomic Instability |
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Protein |
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Participants with greater variability in red cell size were weaker, walked more slowly, and had a worse cognitive function. They were more likely to have functional limitations (35.2% in the highest RDW category vs 16.0% in the lowest, p < .001) and frailty (30.3% vs 11.3%, p < .001). Those with greater variability in red cell size were more likely to develop new functional limitations and to become frail. The risk of having 2 or more falls was also greater (highest 19.2% vs lowest 10.3%, p < .001). The risk of hospitalization was higher in those with the highest variability (odds ratio [95% confidence interval], 1.8 [1.3-2.5]) compared with the lowest. Variability in red cell size was related to total and cause-specific mortality. |
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3635 |
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3635/0 |
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Predictive |
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Greater variability in red cell size is associated with diverse aging-related outcomes, suggesting that it may have potential value as a marker for biological aging. |
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/, J Gerontol A Biol Sci Med Sci, 2021 |
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PMID:32894755 (Click to Pubmed) ； IF: ； Citation: |
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