| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Interleukin-1 beta (IL-1β) |
Category |
Molecular Changes |
Affected targets |
Vascular Aging |
Hallmarks |
Cellular Senescence |
Molecular |
DNA |
Description |
IL-1beta, a senescence-associated secretory phenotype (SASP) gene itself and a biomarker for atherosclerosis, induces cellular senescence also by upregulating CUX1 and/or downregulating SATB2 in human ECs. |
| EXPERIMENT INFORMATION | |
Region |
worldwide |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
Therefore, together, cux1 and satb2 fine-tune the expression of P16(ink4a)via their competitive, but also coordinated binding to the atherosclerosis-associated fsnp rs1537371, which precisely and tightly regulates cellular senescence in human ecs. |
Reference |
Gang Li, Aging Cell, 2023 |
Details |
PMID:36633253 (Click to Pubmed) ； IF: ； Citation: |
Confidence |