| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
GrimAge |
Category |
Molecular Changes |
Affected targets |
Brain Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
DNA |
Description |
Epigenome-wide DNA methylation (DNAm) levels that index biological aging and earlier age of mortality were quantified by a blood-based biomarker called GrimAge. |
| EXPERIMENT INFORMATION | |
Region |
USA |
Race |
multiple racial |
Samples |
3281 |
Age |
69.4 |
Gender |
758/981 |
Application |
Predictive |
Conclusion |
The adhd-pgs was significantly and directly associated with grimage when adjusting for covariates. in single mediation models, the effect of the adhd-pgs on grimage was partially mediated via smoking, depressive symptoms, and education. in multi-mediation models, the effect of the adhd-pgs on grimage was mediated first through education, then smoking, depressive symptoms, bmi, and income. |
Reference |
Eileen M Crimmins, Clin Epigenentics, 2023 |
Details |
PMID:37101297 (Click to Pubmed) ； IF: ； Citation: |
Confidence |