| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Intrarenal Telomere Length |
Category |
Molecular Changes |
Affected targets |
Kidney Aging |
Hallmarks |
Telomere Attrition |
Molecular |
DNA |
Description |
Recently, we demonstrated that arteriosclerosis in the smaller intrarenal arteries is associated with shorter telomere length, independently of history of cardiovascular events and calendar age. |
| EXPERIMENT INFORMATION | |
Region |
worldwide |
Race |
multiple racial |
Samples |
213 |
Age |
48.0±15/48.7±15 |
Gender |
128/85 |
Application |
Functional |
Conclusion |
In conclusion, our study suggests that there is an association between overexpression of intrarenal cholesterol biosynthesis, shorter intrarenal telomere length and increased renal arteriosclerosis in humans, although no causality can be inferred from our data. |
Reference |
Maarten Naesens, Aging (Albany NY), 2020 |
Details |
PMID:32353828 (Click to Pubmed) ； IF: ； Citation: |
Confidence |