| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Autophagy/Mitophagy-Lysosomal System |
Category |
Molecular Changes |
Affected targets |
Skeletal Muscle Aging |
Hallmarks |
Disabled Macroautophagy |
Molecular |
Protein |
Description |
The autophagy–lysosome system is a pivotal component of MQC. Through this system, proteins and organelles are tagged for disposal, engulfed into an autophagosome, and ultimately delivered to the lysosome for degradation |
| EXPERIMENT INFORMATION | |
Region |
worldwide |
Race |
multiple racial |
Samples |
23 |
Age |
77.9±6.3/24.3±4.3 |
Gender |
45637 |
Application |
Functional |
Conclusion |
An altered expression of markers of the autophagy/mitophagy-lysosomal system is related to deterioration of lower extremity tissue composition and muscle dysfunction. additional studies are needed to clarify the role of defective mqc in human muscle aging and identify novel biological targets for drug development. |
Reference |
David A Hood, Cells, 2023 |
Details |
PMID:36611976 (Click to Pubmed) ； IF: ； Citation: |
Confidence |