| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Cyclin F |
Category |
Molecular Changes |
Affected targets |
Kidney Aging |
Hallmarks |
Genomic Instability |
Molecular |
DNA |
Description |
Further studies showed that the reduction of CCNF promoted cell senescence by decreasing cyclin-dependent kinase 1 (CDK1), increasing the proinflammatory factors interleukin (IL)-6 and IL-8, and then enhancing the expression of p21 and p53. |
| EXPERIMENT INFORMATION | |
Region |
China |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
We propose that the high expression of ccnf in kirc may play a key role in tumorigenesis by regulating cell senescence. |
Reference |
Ya-Qi Chen, Curr Med Sci, 2023 |
Details |
PMID:36602672 (Click to Pubmed) ； IF: ； Citation: |
Confidence |