| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Human Epigenetic Clock |
Category |
Molecular Changes |
Affected targets |
Instestinal Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
DNA |
Description |
here are many hallmarks of aging, including cellular senescence, telomere shortening, DNA damage, and gene expression and epigenetic changes. 20At the epigenetic level, genome-wide DNA methylation (DNAm) changes are pervasive during aging, with increased variability in methylation observed over time—a process known as epigeneticdrift. |
| EXPERIMENT INFORMATION | |
Region |
California |
Race |
multiple racial |
Samples |
36 |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
Our data validate the use of organoids as a model for studying human intestinal aging and introduce methods that can be used when modeling aging or age-onset diseases in vitro. |
Reference |
D Leanne Jones, Cell Mol Gastroenterol Hepatol, 2020 |
Details |
PMID:31805439 (Click to Pubmed) ； IF: ； Citation: |
Confidence |