| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Urinary Extracellular Vesicles (EVs) Levels |
Category |
Molecular Changes |
Affected targets |
Kidney Aging |
Hallmarks |
Altered Intercellular Communication |
Molecular |
Protein |
Description |
Cells in distress release extracellular vesicles (EVs), and their numbers in urine may reflect renal injury. |
| EXPERIMENT INFORMATION | |
Region |
USA(Rochester MN) |
Race |
multiple racial |
Samples |
14 |
Age |
72.3(64–79) |
Gender |
45451 |
Application |
Functional |
Conclusion |
Conclusions levels of p16+evs are elevated in urine of hypertensive patients and may reflect increased proximal tubular cellular senescence. in eh, evs originate also from distal tubules and in renovascular hypertension from henle's loop. hence, urinary evs levels may be useful to identify intrarenal sites of cellular senescence. |
Reference |
Lilach O Lerman, J Am Heart Assoc, 2019 |
Details |
PMID:31433703 (Click to Pubmed) ； IF: ； Citation: |
Confidence |