| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Tumor Necrosis Factor Alpha (TNF-α) |
Category |
Cellular Alterations |
Affected targets |
Skeletal Muscle Aging |
Hallmarks |
Loss of Proteostasis |
Molecular |
Other |
Description |
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natural consequent autoantibody to TNF-α, is an indicator of relatively prolonged TNF-α exposure, has more stable concentrations than TNF-α and should be a better alteRNAtive as a biomarker of sarcopenia. |
| EXPERIMENT INFORMATION | |
Region |
Taiwan(China) |
Race |
multiple racial |
Samples |
484 |
Age |
69.3 |
Gender |
241/243 |
Application |
Functional |
Conclusion |
Anti-tnf-α may be a more appropriate biomarker than tnf-α for sarcopenia, but further investigations are needed to confirm its roles in sarcopenia diagnosis and treatment response evaluation. |
Reference |
Liang-Kung Chen, Experimental gerontology, 2022 |
Details |
PMID:36509297 (Click to Pubmed) ； IF: ； Citation: |
Confidence |