| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Insulin-like growth factor-binding protein 2 (IGFBP-2) |
Category |
Molecular Changes |
Affected targets |
Pancreatic Aging |
Hallmarks |
Altered Intercellular Communication |
Molecular |
Other |
Description |
Objective Insulin-like growth factor-binding protein-2 (IGFBP-2) concentrations are low in subjects with metabolic syndrome and type 2 diabetes. Intriguingly, recent studies have demonstrated an association between high IGFBP-2 concentrations and increased mortality not only in populations with certain types of cancer, but also in relatively healthy populations. |
| EXPERIMENT INFORMATION | |
Region |
Netherlands,USA |
Race |
multiple racial |
Samples |
539 |
Age |
/ |
Gender |
324/215 |
Application |
Predictive |
Conclusion |
However, its predictive value for mortality can only be interpreted in relation to insulin sensitivity. after adjustment for insulin sensitivity, high igfbp-2 levels are predictive of increased mortality. |
Reference |
Josephine M Egan, European journal of endocrinology, 2019 |
Details |
PMID:30475224 (Click to Pubmed) ； IF: ； Citation: |
Confidence |