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MicroRNA-126 |
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Cellular Alterations |
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Kidney Aging |
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Cellular Senescence |
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Other |
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Renal senescence is one of the important pathogeneses for DKD, but the mechanism of renal and cellular senescence is unclear. Decreased expression of circulating miR-126 is associated with the development of DKD and may be a promising blood-based biomarker for DKD. |
| EXPERIMENT INFORMATION |
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China |
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multiple racial |
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1640 |
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Anti-Aging |
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The results showed that high glucose not only arrested the cell cycle in g1 phase but also shortened the telomere length. high glucose led to high expression of p53, p21, rb, p-stat1 and p-stat3 and premature senescence of hgmcs by activating the telomere-p53-p21-rb and jak/stat signaling pathways. moreover, the mir-126 was decreased in hgmcs induced by high glucose. it was suggested that the transfection of mir-126 mimics could inhibit the telomere-p53-p21-rb and jak/stat signaling pathway activity in vitro and delay the senescence of hgmcs. the results may serve as a new strategy for the treatment of dkd. |
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Xiao Han, Current medical science, 2018 |
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PMID:30341510 (Click to Pubmed) ； IF: ； Citation: |
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