| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
MTS1 (Multiple Tumor Suppressor 1) |
Category |
Molecular Changes |
Affected targets |
Instestinal Aging |
Hallmarks |
Cellular Senescence |
Molecular |
DNA |
Description |
We analyzed the impact of P16(ink4a)expression, a hallmark of cellular senescence, in intestinal biopsies of patients with lower GI GVHD symptoms and NFKB1 gene polymorphisms (rs3774937 C/T and rs3774959 A/G) on HSCT outcome. |
| EXPERIMENT INFORMATION | |
Region |
Czech Republic |
Race |
multiple racial |
Samples |
52 |
Age |
/ |
Gender |
26/26 |
Application |
Functional |
Conclusion |
Our results address possible new mechanisms that may lead to better understanding of hsct-related immune complications. cellular senescence may bring novel approaches in gvhd diagnostics and therapy. |
Reference |
Tomas Papajik, Transplant immunology, 2022 |
Details |
PMID:36470572 (Click to Pubmed) ； IF: ； Citation: |
Confidence |