| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Senolytic Agents |
Category |
Cellular Alterations |
Affected targets |
Vascular Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
Here we report a molecular design to tackle this challenge through multidimensional, hierarchical recognition of three hallmarks commonly shared among senescence, namely, aptamer-mediated recognition of a membrane marker for active cell targeting, a self-immolative linker responsive to lysosomal enzymes for switchable drug release, and a compound against antiapoptotic signaling for clearance. |
| EXPERIMENT INFORMATION | |
Region |
China |
Race |
multiple racial |
Samples |
/ |
Age |
/ |
Gender |
/ |
Application |
Anti-Aging |
Conclusion |
Its potential for in vivo treatment of vascular diseases is successfully illustrated in a model of atherosclerosis, with effective suppression of the plaque progression yet negligible side effects. |
Reference |
Yanlan Liu, Angewandte Chemie (International ed. in English), 2022 |
Details |
PMID:36445796 (Click to Pubmed) ； IF: ； Citation: |
Confidence |