| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Stromal Interaction Molecule 1 (STIM1) and Orai Calcium Release-Activated Calcium Modulator (ORAI) |
Category |
Molecular Changes |
Affected targets |
Vascular Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Protein |
Description |
Different systems control the cell's capacity to manage the calcium level, where the store-operated calcium entry (SOCE) through stromal interaction molecule (STIM)-gated Orai channels plays a key role |
| EXPERIMENT INFORMATION | |
Region |
Spain |
Race |
white |
Samples |
30/15 |
Age |
43/73.7 |
Gender |
31/14 |
Application |
Functional |
Conclusion |
Aging is associated with an increased expression of the stim/orai system in human vessels with functional relevance only in the microvascular territory, suggesting its role in aging-related microvascular dysfunction. |
Reference |
Javier Angulo, Cells, 2022 |
Details |
PMID:36429103 (Click to Pubmed) ； IF: ； Citation: |
Confidence |