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DNA Methylation (DNAm) |
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Molecular Changes |
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Skeletal Aging |
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Epigenetic Alterations |
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DNA |
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DNA methylation (DNAm) plays an essential role in various biological processes such as embryonic development, cellular differentiation, and gene expression regulation. Over the last decade, several groups have independently evaluated the methylation levels of DNA extracted from blood and demonstrated a high correlation between DNA methylation (DNAm) levels and chronological age. |
| EXPERIMENT INFORMATION |
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Japan |
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multiple racial |
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59/40 |
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/ |
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57/41(and one unknown sex) |
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Predictive |
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We assessed the methylation ofelovl2andedaraddin 59 tooth samples using rt-msp and developed a multiple regression model, the mae value of which was 6.69 years. the accuracy of the age estimation model was verified using an additional 40 extracted teeth; the obtained mae value was 8.28 years, which was close to that obtained for the training samples. this result indicates that our multiple regression model can be used for dental age estimation. |
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Masaaki Yoshikawa, Forensic Sci Int., 2022 |
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PMID:36108573 (Click to Pubmed) ； IF: ； Citation: |
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