| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
DNA Methylation (DNAm) |
Category |
Molecular Changes |
Affected targets |
Cardiac Aging |
Hallmarks |
Epigenetic Alterations |
Molecular |
DNA |
Description |
Methylation status at these CpG sites has been reported to relate to chronic diseases, including metabolic syndrome, heart disease, stroke, cancer, and mortality, even after adjusting for age and other traditional risk factors. |
| EXPERIMENT INFORMATION | |
Region |
USA |
Race |
multiple racial |
Samples |
2435 |
Age |
54.9±14.3 |
Gender |
697/817 |
Application |
Functional |
Conclusion |
In the current study, we provide evidence to suggest that habitual physical activity and sedentary time were associated with dna methylation status on markers associated with mortality and older age. bmi only partially explains these associations. further research could explore whether these and other markers of methylation status can be modified by changes in lifestyle habits and whether those modifications to methylation status confer influence on disease risk. |
Reference |
Nicole Spartano, Med Sci Sports Exerc, 2023 |
Details |
PMID:36107108 (Click to Pubmed) ； IF: ； Citation: |
Confidence |