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Senescence-Associated Secretory Phenotype (SASP) |
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Cellular Alterations |
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Liver Aging |
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Cellular Senescence |
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Protein |
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The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development. |
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Germany |
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Anti-Aging |
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Arsenite exposure induces premature senescence in human hepatic stellate cells, followed by sasp induction, and the effects of arsenite exposure persist even after cessation of arsenite exposure (fig. 10). clearance of senescent cells is a new therapeutic strategy for age-related diseases (baker et al., 2011; kirkland and tchkonia, 2020). the removal of senescent cells has been shown to be effective for preventing the development of hcc (wang et al., 2019; wakita et al., 2020). therefore, premature senescence induced by arsenite exposure could be a potential therapeutic target for arsenite exposure-induced carcinogenesis. |
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Kazuyuki Okamura, Toxicol Appl Pharmacol., 2022 |
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PMID:36089002 (Click to Pubmed) ； IF: ； Citation: |
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