| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Cyclin-dependent kinase inhibitor 1A (CDKN1A) |
Category |
Molecular Changes |
Affected targets |
Liver Aging |
Hallmarks |
Cellular Senescence |
Molecular |
DNA |
Description |
The protein p21 is encoded by CDKN1A. Studies in diverse conditions showed that CDKN1A variants are associated with the rate of disease progression. |
| EXPERIMENT INFORMATION | |
Region |
UK/Finland |
Race |
multiple racial |
Samples |
446 |
Age |
52.0(UK)/46.0(Finland) |
Gender |
250/196 |
Application |
Functional |
Conclusion |
Cdkn1a variant rs762623( involved in cellular senescence) is associated with the development but not the propagation of progressive liver disease in nafld. |
Reference |
Graeme Alexander, Cell Cycle., 2014 |
Details |
PMID:24626178 (Click to Pubmed) ； IF: ； Citation: |
Confidence |