| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
p21 (CDKN1A) |
Category |
Cellular Alterations |
Affected targets |
Liver Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Protein |
Description |
Irreversible cell cycle arrest that limits the proliferative potential of cells is a feature of cellular senescence and is mediated by p21, a universal cell cycle inhibitor [10]. p21 also contributes to the stability of cell cycle arrest long after the induction of senescence [10]. |
| EXPERIMENT INFORMATION | |
Region |
UK |
Race |
/ |
Samples |
119 |
Age |
26-80 |
Gender |
73/46 |
Application |
Predictive |
Conclusion |
The findings are consistent with impaired cell cycle progression beyond the g1/s phase in ald. the striking independent associations between increased hepatocyte p21 expression and both fibrosis stage and an adverse liver-related outcome in both cohorts suggests hepatocyte senescence plays an important role in ald. measuring hepatocyte p21 expression is simple and cheap and in this series was a useful measure of long-term prognosis in ald. |
Reference |
Graeme J. M. Alexander, PLoS One, 2013 |
Details |
PMID:24086266 (Click to Pubmed) ； IF: ； Citation: |
Confidence |