| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
Histone H2A.J |
Category |
Cellular Alterations |
Affected targets |
Skin Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Other |
Description |
Previous studies have shown that histone variant H2A.J accumulates in human fibroblasts during replicative and radiation-induced senescence and modulates the secretion of inflammatory cytokines. Our previous research shows that H2A.J is a sensitive marker of senescent keratinocytes in the human epidermis in the context of skin aging. |
| EXPERIMENT INFORMATION | |
Region |
Germany |
Race |
multiple racial |
Samples |
12 |
Age |
1–9 |
Gender |
36861 |
Application |
Functional |
Conclusion |
Cultured foreskin characterized by highly keratinized epithelium and specific immunological features is not an appropriate model for studying h2a.j-associated tissue reactions during radiation-induced dermatitis. |
Reference |
Claudia E Rübe, Int J Mol Sci., 2022 |
Details |
PMID:36077226 (Click to Pubmed) ； IF: ； Citation: |
Confidence |